Retraining speech production and fluency in non-fluent/agrammatic primary progressive aphasia

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Connected speech production in three variants of primary progressive aphasia.

Primary progressive aphasia is a clinical syndrome defined by progressive deficits isolated to speech and/or language, and can be classified into non-fluent, semantic and logopenic variants based on motor speech, linguistic and cognitive features. The connected speech of patients with primary progressive aphasia has often been dichotomized simply as 'fluent' or 'non-fluent', however fluency is ...

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BACKGROUND: Classical aphasiology, based on the study of stroke sequelae, fuses speech fluency and grammatical ability. Nonfluent (Broca's) aphasia often is accompanied by agrammatism; whereas in the fluent aphasias grammatical deficits are not typical. The assumption that a similar relationship exists in primary progressive aphasia (PPA) has led to the dichotomization of this syndrome into flu...

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The nature and frequency of speech production errors in neurodegenerative disease have not previously been precisely quantified. In the present study, 16 patients with a progressive form of non-fluent aphasia (PNFA) were asked to tell a story from a wordless children's picture book. Errors in production were classified as either phonemic, involving language-based deformations that nevertheless ...

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Automatic speech recognition in the diagnosis of primary progressive aphasia

Narrative speech can provide a valuable source of information about an individual’s linguistic abilities across lexical, syntactic, and pragmatic levels. However, analysis of narrative speech is typically done by hand, and is therefore extremely time-consuming. Use of automatic speech recognition (ASR) software could make this type of analysis more efficient and widely available. In this paper,...

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Speech Therapy in Primary Progressive Aphasia: A Pilot Study

BACKGROUND Primary progressive aphasia (PPA) is a neurodegenerative disorder with no effective pharmacological treatment. Cognition-based interventions are adequate alternatives, but their benefit has not been thoroughly explored. Our aim was to study the effect of speech and language therapy (SLT) on naming ability in PPA. METHODS An open parallel prospective longitudinal study involving two...

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ژورنال

عنوان ژورنال: Brain

سال: 2018

ISSN: 0006-8950,1460-2156

DOI: 10.1093/brain/awy101